Prednisone vs. Prednisolone: Which One to Choose?

The development and enlargement of the pharmaceutical market are definitely advantageous issues, though they create extra differences for patients who need some treatment. People who are diagnosed with inflammation should select from multiple similar drugs, including Prednisone and Prednisolone. Both medications are used to prevent the release of harmful substances in the organism that cause inflammation. Additionally, both drugs are prescribed to patients with diverse allergic disorders, ulcerative colitis, lupus, breathing problems, psoriasis, skin issues and others. Additionally, the medications can suppress the immune system, producing numerous health improvements. Both Prednisone and Prednisolone can be used in other cases not mentioned in the safety leaflet.

Similarities and Differences of Prednisone and Prednisolone

Viewing the drugs as alternative treatments of the same health conditions, one should consider all the benefits and drawbacks of each medication before making a decision. The main difference between the two is that Prednisone is the precursor to the Prednisolone. Thus, Prednisone gets activated by the enzymes found in the liver to transfer into Prednisolone. While both drugs are safe and effective, have similar uses and precautions, Prednisolone is regarded to be more readily absorbed by the organism. That is why, Prednisolone is recommended for the patients with liver failure of liver toxicity involved.

Other crucial discrepancies between Prednisone and Prednisolone are diverse molecular weight and structures. Besides, Prednisone is available in the tablet form only, while Prednisolone can be administered orally, topically and also injected. Moreover, Prednisolone produces more drastic and powerful anti-inflammatory effect.

Apart from the differences mentioned, Prednisone and Prednisolone are similar in all the other features. They both belong to a group of corticosteroids that produce severe anti-inflammatory effect. The two treatments are recommended for the patients suffering from acute or chronic inflammations. Moreover, Prednisone and Prednisolone work suppressing the immune system to prevent the rejection of transplanted organs. Since the medications suppress the adrenal glands, their prolonged administration can lead to improper work of the adrenals. It is vital to follow doctor’s recommendations while taking any of these drugs, since they both cause severe complications if misused or overused. It is not advised to stop Prednisone or Prednisolone intake abruptly, as it can activate undesirable withdrawal effects and other reactions.